This is the list of all references cited in senescence.info. Often, I cite my own academic publications for the simple reason that I am more familiar with them. For the sake of brevity I do not cite every single paper related to a given topic, and I frequently cite review papers and books--though I try to cite the most important original research papers. Lastly, please see my list of links and books for additional sources of information.
Ackermann, M., Stearns, S. C., and Jenal, U. (2003). "Senescence in a bacterium with asymmetric division." Science 300(5627):1920. PubMed
Adelman, R. C. (1998). "The Alzheimerization of aging: a brief update." Exp Gerontol 33(1-2):155-157. PubMed
Ahmed, S., and Hodgkin, J. (2000). "MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans." Nature 403(6766):159-164. PubMed
Aikata, H., Takaishi, H., Kawakami, Y., Takahashi, S., Kitamoto, M., Nakanishi, T., Nakamura, Y., Shimamoto, F., Kajiyama, G., and Ide, T. (2000). "Telomere reduction in human liver tissues with age and chronic inflammation." Exp Cell Res 256(2):578-582. PubMed
Alaluf, S., Muir-Howie, H., Hu, H. L., Evans, A., and Green, M. R. (2000). "Atmospheric oxygen accelerates the induction of a post-mitotic phenotype in human dermal fibroblasts: the key protective role of glutathione." Differentiation 66(2-3):147-155. PubMed
Alcendor, R. R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., Tian, B., Wagner, T., Vatner, S. F., and Sadoshima, J. (2007). "Sirt1 regulates aging and resistance to oxidative stress in the heart." Circ Res 100(10):1512-1521. PubMed
Alcorta, D. A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., and Barrett, J. C. (1996). "Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts." Proc Natl Acad Sci U S A 93(24):13742-13747. PubMed
Allman, J., McLaughlin, T., and Hakeem, A. (1993). "Brain weight and life-span in primate species." Proc Natl Acad Sci U S A 90(1):118-122. PubMed
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., and Harley, C. B. (1992). "Telomere length predicts replicative capacity of human fibroblasts." Proc Natl Acad Sci U S A 89(21):10114-10118. PubMed
Altman, J., and Das, G. D. (1965). "Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats." J Comp Neurol 124(3):319-335. PubMed
Ames, B. N., Cathcart, R., Schwiers, E., and Hochstein, P. (1981). "Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis." Proc Natl Acad Sci U S A 78(11):6858-6862. PubMed
Ames, B. N., Shigenaga, M. K., and Hagen, T. M. (1993). "Oxidants, antioxidants, and the degenerative diseases of aging." Proc Natl Acad Sci U S A 90(17):7915-7922. PubMed
Andziak, B., O'Connor T, P., and Buffenstein, R. (2005). "Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat." Mech Ageing Dev 126(11):1206-1212. PubMed
Anisimov, V. N., Zavarzina, N. Y., Zabezhinski, M. A., Popovich, I. G., Zimina, O. A., Shtylick, A. V., Arutjunyan, A. V., Oparina, T. I., Prokopenko, V. M., Mikhalski, A. I., et al. (2001). "Melatonin increases both life span and tumor incidence in female CBA mice." J Gerontol A Biol Sci Med Sci 56(7):B311-323. PubMed
Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Kovalenko, I. G., Poroshina, T. E., Semenchenko, A. V., Provinciali, M., et al. (2005). "Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice." Exp Gerontol 40(8-9):685-693. PubMed
Antonawich, F. J., Federoff, H. J., and Davis, J. N. (1999). "BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia." Exp Neurol 156(1):130-137. PubMed
Apfeld, J., and Kenyon, C. (1998). "Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span." Cell 95(2):199-210. PubMed
Arantes-Oliveira, N., Apfeld, J., Dillin, A., and Kenyon, C. (2002). "Regulation of life-span by germ-line stem cells in Caenorhabditis elegans." Science 295(5554):502-505. PubMed
Arking, D. E., Krebsova, A., Macek, M., Sr., Macek, M., Jr., Arking, A., Mian, I. S., Fried, L., Hamosh, A., Dey, S., McIntosh, I., et al. (2002). "Association of human aging with a functional variant of klotho." Proc Natl Acad Sci U S A 99(2):856-861. PubMed
Artandi, S. E., Alson, S., Tietze, M. K., Sharpless, N. E., Ye, S., Greenberg, R. A., Castrillon, D. H., Horner, J. W., Weiler, S. R., Carrasco, R. D., et al. (2002). "Constitutive telomerase expression promotes mammary carcinomas in aging mice." Proc Natl Acad Sci U S A 99(12):8191-8196. PubMed
Atadja, P., Wong, H., Garkavtsev, I., Veillette, C., and Riabowol, K. (1995). "Increased activity of p53 in senescing fibroblasts." Proc Natl Acad Sci U S A 92(18):8348-8352. PubMed
Austad, S. N. (1988). "The adaptable opossum." Sci Am (Feb.):98-104.
Austad, S. N. (1989). "Life extension by dietary restriction in the bowl and doily spider, Frontinella pyramitela." Exp Gerontol 24(1):83-92. PubMed
Austad, S. N., and Fischer, K. E. (1991). "Mammalian aging, metabolism, and ecology: evidence from the bats and marsupials." J Gerontol 46(2):B47-53. PubMed
Austad, S. N. (1997b). "Comparative aging and life histories in mammals." Exp Gerontol 32(1-2):23-38. PubMed
Austad, S. N. (1997c). "Small nonhuman primates as potential models of human aging." Ilar J 38(3):142-147. PubMed
Austad, S. N. (2001). "An experimental paradigm for the study of slowly aging organisms." Exp Gerontol 36(4-6):599-605. PubMed
Austad, S. N. (2004). "Is aging programed?" Aging Cell 3(5):249-251. PubMed
Austad, S. N. (2005). "Diverse aging rates in metazoans: targets for functional genomics." Mech Ageing Dev 126(1):43-49. PubMed
Balin, A. K. E. (1994). Practical Handbook of Biologic Age Determination. CRC Press, Boca Raton, FL.
Barja, G., and Herrero, A. (2000). "Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals." Faseb J 14(2):312-318. PubMed
Barja, G. (2002). "Endogenous oxidative stress: relationship to aging, longevity and caloric restriction." Ageing Res Rev 1(3):397-411. PubMed
Barker, M. G., and Walmsley, R. M. (1999). "Replicative ageing in the fission yeast Schizosaccharomyces pombe." Yeast 15(14):1511-1518. PubMed
Bartke, A., Coschigano, K., Kopchick, J., Chandrashekar, V., Mattison, J., Kinney, B., and Hauck, S. (2001a). "Genes that prolong life: relationships of growth hormone and growth to aging and life span." J Gerontol A Biol Sci Med Sci 56(8):B340-349. PubMed
Bartke, A., Wright, J. C., Mattison, J. A., Ingram, D. K., Miller, R. A., and Roth, G. S. (2001b). "Extending the lifespan of long-lived mice." Nature 414(6862):412. PubMed
Bartke, A. (2003). "Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice." Neuroendocrinology 78(4):210-216. PubMed
Bartke, A. (2005). "Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging." Endocrinology 146(9):3718-3723. PubMed
Barton-Davis, E. R., Shoturma, D. I., Musaro, A., Rosenthal, N., and Sweeney, H. L. (1998). "Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function." Proc Natl Acad Sci U S A 95(26):15603-15607. PubMed
Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., and Partridge, L. (2007). "Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans." Mech Ageing Dev 128(10):546-552. PubMed
Bassham, S., Beam, A., and Shampay, J. (1998). "Telomere variation in Xenopus laevis." Mol Cell Biol 18(1):269-275. PubMed
Bastianetto, S., and Quirion, R. (2002). "Natural extracts as possible protective agents of brain aging." Neurobiol Aging 23(5):891-897. PubMed
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006). "Resveratrol improves health and survival of mice on a high-calorie diet." Nature 444(7117):337-342. PubMed
Baur, J. A., and Sinclair, D. A. (2006). "Therapeutic potential of resveratrol: the in vivo evidence." Nat Rev Drug Discov 5(6):493-506. PubMed
Bayne, A. C., Mockett, R. J., Orr, W. C., and Sohal, R. S. (2005). "Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila." Biochem J 391(Pt 2):277-284. PubMed
Bayreuther, K., Rodemann, H. P., Hommel, R., Dittmann, K., Albiez, M., and Francz, P. I. (1988). "Human skin fibroblasts in vitro differentiate along a terminal cell lineage." Proc Natl Acad Sci U S A 85(14):5112-5116. PubMed
Beckman, K. B., and Ames, B. N. (1998). "The free radical theory of aging matures." Physiol Rev 78(2):547-581. PubMed
Benard, C., and Hekimi, S. (2002). "Long-lived mutants, the rate of aging, telomeres and the germline in Caenorhabditis elegans." Mech Ageing Dev 123(8):869-880. PubMed
Berardi, P., Meyyappan, M., and Riabowol, K. T. (2003). "A novel transcriptional inhibitory element differentially regulates the cyclin D1 gene in senescent cells." J Biol Chem 278(9):7510-7519. PubMed
Bergquist, D. C., Williams, F. M., and Fisher, C. R. (2000). "Longevity record for deep-sea invertebrate." Nature 403(6769):499-500. PubMed
Berner, Y. N., and Stern, F. (2004). "Energy restriction controls aging through neuroendocrine signal transduction." Ageing Res Rev 3(2):189-198. PubMed
Berzlanovich, A. M., Keil, W., Waldhoer, T., Sim, E., Fasching, P., and Fazeny-Dorner, B. (2005). "Do centenarians die healthy? An autopsy study." J Gerontol A Biol Sci Med Sci 60(7):862-865. PubMed
Besson, A., Salemi, S., Gallati, S., Jenal, A., Horn, R., Mullis, P. S., and Mullis, P. E. (2003). "Reduced longevity in untreated patients with isolated growth hormone deficiency." J Clin Endocrinol Metab 88(8):3664-3667. PubMed
Bidder, G. P. (1932). "Senescence." Brit Med J 2:583-585.
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., and Gluud, C. (2007). "Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis." Jama 297(8):842-857. PubMed
Bjorklund, A., and Lindvall, O. (2000). "Self-repair in the brain." Nature 405(6789):892-893, 895. PubMed
Blackburn, E. H. (2000). "Telomere states and cell fates." Nature 408(6808):53-56. PubMed
Blackman, M. R., Sorkin, J. D., Munzer, T., Bellantoni, M. F., Busby-Whitehead, J., Stevens, T. E., Jayme, J., O'Connor, K. G., Christmas, C., Tobin, J. D., et al. (2002). "Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial." Jama 288(18):2282-2292. PubMed
Blake, M. J., Fargnoli, J., Gershon, D., and Holbrook, N. J. (1991). "Concomitant decline in heat-induced hyperthermia and HSP70 mRNA expression in aged rats." Am J Physiol 260(4 Pt 2):R663-R667. PubMed
Blasco, M. A., Lee, H. W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., and Greider, C. W. (1997). "Telomere shortening and tumor formation by mouse cells lacking telomerase RNA." Cell 91(1):25-34. PubMed
Blasco, M. A., and Hahn, W. C. (2003). "Evolving views of telomerase and cancer." Trends Cell Biol 13(6):289-294. PubMed
Blasco, M. A. (2005). "Telomeres and human disease: ageing, cancer and beyond." Nat Rev Genet 6(8):611-622. PubMed
Bodkin, N. L., Alexander, T. M., Ortmeyer, H. K., Johnson, E., and Hansen, B. C. (2003). "Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction." J Gerontol A Biol Sci Med Sci 58(3):212-219. PubMed
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C. P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., and Wright, W. E. (1998). "Extension of life-span by introduction of telomerase into normal human cells." Science 279(5349):349-352. PubMed
Bohr, V. A., Brosh, R. M., Jr., von Kobbe, C., Opresko, P., and Karmakar, P. (2002). "Pathways defective in the human premature aging disease Werner syndrome." Biogerontology 3(1-2):89-94. PubMed
Bonafe, M., Barbieri, M., Marchegiani, F., Olivieri, F., Ragno, E., Giampieri, C., Mugianesi, E., Centurelli, M., Franceschi, C., and Paolisso, G. (2003). "Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control." J Clin Endocrinol Metab 88(7):3299-3304. PubMed
Bond, J., Haughton, M., Blaydes, J., Gire, V., Wynford-Thomas, D., and Wyllie, F. (1996). "Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence." Oncogene 13(10):2097-2104. PubMed
Bonelli, M. A., Alfieri, R. R., Petronini, P. G., Brigotti, M., Campanini, C., and Borghetti, A. F. (1999). "Attenuated expression of 70-kDa heat shock protein in WI-38 human fibroblasts during aging in vitro." Exp Cell Res 252(1):20-32. PubMed
Bons, N., Mestre, N., and Petter, A. (1992). "Senile plaques and neurofibrillary changes in the brain of an aged lemurian primate, Microcebus murinus." Neurobiol Aging 13(1):99-105. PubMed
Bowles, J. (2000). "Shattered: Medawar's test tubes and their enduring legacy of chaos." Med Hypotheses 54(2):326-339. PubMed
Brack, C., Lithgow, G., Osiewacz, H., and Toussaint, O. (2000). "EMBO WORKSHOP REPORT: Molecular and cellular gerontology Serpiano, Switzerland, September 18-22, 1999." Embo J 19(9):1929-1934. PubMed
Brakefield, P. M., Gems, D., Cowen, T., Christensen, K., Grubeck-Loebenstein, B., Keller, L., Oeppen, J., Rodriguez-Pena, A., Stazi, M. A., Tatar, M., et al. (2005). "What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models?" Mech Ageing Dev 126(3):431-438. PubMed
Breese, C. R., Ingram, R. L., and Sonntag, W. E. (1991). "Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins." J Gerontol 46(5):B180-187. PubMed
Brocas, J., and Verzar, F. (1961). "The aging of Xenopus laevis, a South African frog." Gerontologia 5:228-240. PubMed
Brock, M. A., and Strehler, B. L. (1963). "Studies on the comparative physiology of aging. IV. Age and mortality of some marine Cnidaria in the laboratory." J Gerontol 18:23-28. PubMed
Brock, T. D. (1997). Biology of Microorganisms. Prentice Hall & IBD, New Jersey.
Brockes, J. P., Kumar, A., and Velloso, C. P. (2001). "Regeneration as an evolutionary variable." J Anat 199(Pt 1-2):3-11. PubMed
Bronikowski, A. M., Alberts, S. C., Altmann, J., Packer, C., Carey, K. D., and Tatar, M. (2002). "The aging baboon: comparative demography in a non-human primate." Proc Natl Acad Sci U S A 99(14):9591-9595. PubMed
Brown-Borg, H. M., Borg, K. E., Meliska, C. J., and Bartke, A. (1996). "Dwarf mice and the ageing process." Nature 384(6604):33. PubMed
Brown-Borg, H. M., Rakoczy, S. G., and Uthus, E. O. (2005). "Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice." Mech Ageing Dev 126(3):389-398. PubMed
Brunet-Rossinni, A. K., and Austad, S. N. (2004). "Ageing studies on bats: a review." Biogerontology 5(4):211-222. PubMed
Brunk, U., Ericsson, J. L., Ponten, J., and Westermark, B. (1973). "Residual bodies and "aging" in cultured human glia cells. Effect of entrance into phase 3 and prolonged periods of confluence." Exp Eye Res 79(1):1-14. PubMed
Brunmark, A., Collins, V. P., Thaw, H., and Brunk, U. (1986). "Lipofuscin accumulation in cultured non-dividing cells as a function of time and oxygen tension." Scan Electron Microsc 1:189-192. PubMed
Bryan, T. M., Englezou, A., Gupta, J., Bacchetti, S., and Reddel, R. R. (1995). "Telomere elongation in immortal human cells without detectable telomerase activity." Embo J 14(17):4240-4248. PubMed
Buchkovich, K., Duffy, L. A., and Harlow, E. (1989). "The retinoblastoma protein is phosphorylated during specific phases of the cell cycle." Cell 58(6):1097-1105. PubMed
Buffenstein, R., and Jarvis, J. U. (2002). "The naked mole rat--a new record for the oldest living rodent." Sci Aging Knowledge Environ 2002(21):pe7. PubMed
Bukovsky, A., Caudle, M. R., Svetlikova, M., Wimalasena, J., Ayala, M. E., and Dominguez, R. (2005). "Oogenesis in adult mammals, including humans: a review." Endocrine 26(3):301-316. PubMed
Burck, U., Goebel, H. H., Kuhlendahl, H. D., Meier, C., and Goebel, K. M. (1981). "Neuromyopathy and vitamin E deficiency in man." Neuropediatrics 12(3):267-278. PubMed
Butler, R. N., Austad, S. N., Barzilai, N., Braun, A., Helfand, S., Larsen, P. L., McCormick, A. M., Perls, T. T., Shuldiner, A. R., Sprott, R. L., et al. (2003). "Longevity genes: from primitive organisms to humans." J Gerontol A Biol Sci Med Sci 58(7):581-584. PubMed
Cailliet, G. M., Andrews, A. H., Burton, E. J., Watters, D. L., Kline, D. E., and Ferry-Graham, L. A. (2001). "Age determination and validation studies of marine fishes: do deep- dwellers live longer?" Exp Gerontol 36(4-6):739-764. PubMed
Calder, W. A. (1984). Size, Function, and Life History. Harvard University Press, Cambridge.
Campisi, J. (2000). "Aging, chromatin, and food restriction--connecting the dots." Science 289(5487):2062-2063. PubMed
Campisi, J., Kim, S. H., Lim, C. S., and Rubio, M. (2001). "Cellular senescence, cancer and aging: the telomere connection." Exp Gerontol 36(10):1619-1637. PubMed
Cao, L., Li, W., Kim, S., Brodie, S. G., and Deng, C. X. (2003). "Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform." Genes Dev 17(2):201-213. PubMed
Carlson, B. M. (2003). "Muscle regeneration in amphibians and mammals: passing the torch." Dev Dyn 226(2):167-181. PubMed
Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., 3rd, Hays, L., Morgan, W. F., and Petrini, J. H. (1998). "The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response." Cell 93(3):477-486. PubMed
Carroll, S. B. (2003). "Genetics and the making of Homo sapiens." Nature 422(6934):849-857. PubMed
Castro, P., Giri, D., Lamb, D., and Ittmann, M. (2003). "Cellular senescence in the pathogenesis of benign prostatic hyperplasia." Prostate 55(1):30-38. PubMed
Cavazzana-Calvo, M., Hacein-Bey, S., de Saint Basile, G., Gross, F., Yvon, E., Nusbaum, P., Selz, F., Hue, C., Certain, S., Casanova, J. L., et al. (2000). "Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease." Science 288(5466):669-672. PubMed
Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., and Kerber, R. A. (2003). "Association between telomere length in blood and mortality in people aged 60 years or older." Lancet 361(9355):393-395. PubMed
Celli, J., Duijf, P., Hamel, B. C., Bamshad, M., Kramer, B., Smits, A. P., Newbury-Ecob, R., Hennekam, R. C., Van Buggenhout, G., van Haeringen, A., et al. (1999). "Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome." Cell 99(2):143-153. PubMed
Cenci, G., Ciapponi, L., and Gatti, M. (2005). "The mechanism of telomere protection: a comparison between Drosophila and humans." Chromosoma 114(3):135-145. PubMed
Chai, Y., and Slavkin, H. C. (2003). "Prospects for tooth regeneration in the 21st century: a perspective." Microsc Res Tech 60(5):469-479. PubMed
Chan, A. W., Chong, K. Y., Martinovich, C., Simerly, C., and Schatten, G. (2001). "Transgenic monkeys produced by retroviral gene transfer into mature oocytes." Science 291(5502):309-312. PubMed
Charlesworth, B., and Hughes, K. A. (1996). "Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence." Proc Natl Acad Sci U S A 93(12):6140-6145. PubMed
Charlesworth, B. (2000). "Fisher, Medawar, Hamilton and the evolution of aging." Genetics 156(3):927-931. PubMed
Chen, J. J., and Yu, B. P. (1994). "Alterations in mitochondrial membrane fluidity by lipid peroxidation products." Free Radical Biol Med 17(5):411-418. PubMed
Chen, Q., Fischer, A., Reagan, J. D., Yan, L. J., and Ames, B. N. (1995). "Oxidative DNA damage and senescence of human diploid fibroblast cells." Proc Natl Acad Sci U S A 92(10):4337-4341. PubMed
Chen, H. J., Liang, C. L., Lu, K., Lin, J. W., and Cho, C. L. (2000). "Implication of telomerase activity and alternations of telomere length in the histologic characteristics of intracranial meningiomas." Cancer 89(10):2092-2098. PubMed
Chen, L., Lee, L., Kudlow, B. A., Dos Santos, H. G., Sletvold, O., Shafeghati, Y., Botha, E. G., Garg, A., Hanson, N. B., Martin, G. M., et al. (2003). "LMNA mutations in atypical Werner's syndrome." Lancet 362(9382):440-445. PubMed
Chiu, C. P., Dragowska, W., Kim, N. W., Vaziri, H., Yui, J., Thomas, T. E., Harley, C. B., and Lansdorp, P. M. (1996). "Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow." Stem Cells 14(2):239-248. PubMed
Choi, H. S., Lin, Z., Li, B. S., and Liu, A. Y. (1990). "Age-dependent decrease in the heat-inducible DNA sequence-specific binding activity in human diploid fibroblasts." J Biol Chem 265(29):18005-18011. PubMed
Choi, D., Whittier, P. S., Oshima, J., and Funk, W. D. (2001). "Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains." Faseb J 15(6):1014-1020. PubMed
Cibelli, J. B., Stice, S. L., Golueke, P. J., Kane, J. J., Jerry, J., Blackwell, C., Ponce de Leon, F. A., and Robl, J. M. (1998). "Cloned transgenic calves produced from nonquiescent fetal fibroblasts." Science 280(5367):1256-1258. PubMed
Cibelli, J. B., Lanza, R. P., West, M. D., and Ezzell, C. (2002). "The first human cloned embryo." Sci Am 286(1):44-51. PubMed
Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., and Partridge, L. (2001). "Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein." Science 292(5514):104-106. PubMed
Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., and Sinclair, D. A. (2004). "Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase." Science 305(5682):390-392. PubMed
Coles, L. S. (2004). "Demographics of human supercentenarians and the implications for longevity medicine." Ann N Y Acad Sci 1019:490-495. PubMed
Colgin, L. M., and Reddel, R. R. (1999). "Telomere maintenance mechanisms and cellular immortalization." Curr Opin Genet Dev 9(1):97-103. PubMed
Collins, K., and Mitchell, J. R. (2002). "Telomerase in the human organism." Oncogene 21(4):564-579. PubMed
Comfort, A. (1964). Ageing: The Biology of Senescence. Routledge & Kegan Paul, London.
Comfort, A., Youhotsky-Gore, I., and Pathmanathan, K. (1971). "Effect of ethoxyquin on the longevity of C3H mice." Nature 229(5282):254-255. PubMed
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., and Rando, T. A. (2005). "Rejuvenation of aged progenitor cells by exposure to a young systemic environment." Nature 433(7027):760-764. PubMed
Congdon, J. D., Nagle, R. D., Kinney, O. M., and van Loben Sels, R. C. (2001). "Hypotheses of aging in a long-lived vertebrate, Blanding's turtle (Emydoidea blandingii)." Exp Gerontol 36(4-6):813-827. PubMed
Congdon, J. D., Nagle, R. D., Kinney, O. M., van Loben Sels, R. C., Quinter, T., and Tinkle, D. W. (2003). "Testing hypotheses of aging in long-lived painted turtles (Chrysemys picta)." Exp Gerontol 38(7):765-772. PubMed
Cook, R. E. (1983). "Clonal plant populations." Am Sci 71:244-253.
Cooper, T. M., Mockett, R. J., Sohal, B. H., Sohal, R. S., and Orr, W. C. (2004). "Effect of caloric restriction on life span of the housefly, Musca domestica." Faseb J 18(13):1591-1593. PubMed
Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., Beal, M. F., and Wallace, D. C. (1992). "Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age." Nat Genet 2(4):324-329. PubMed
Cortopassi, G. A., and Wang, E. (1996). "There is substantial agreement among interspecies estimates of DNA repair activity." Mech Ageing Dev 91(3):211-218. PubMed
Coschigano, K. T., Clemmons, D., Bellush, L. L., and Kopchick, J. J. (2000). "Assessment of growth parameters and life span of GHR/BP gene-disrupted mice." Endocrinology 141(7):2608-2613. PubMed
Cosgrove, G. E., Selby, P. B., Upton, A. C., Mitchell, T. J., Steele, M. H., and Russell, W. L. (1993). "Lifespan and autopsy findings in the first-generation offspring of X-irradiated male mice." Mutat Res 319(1):71-79. PubMed
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., and Bacchetti, S. (1992). "Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity." Embo J 11(5):1921-1929. PubMed
Counter, C. M., Gupta, J., Harley, C. B., Leber, B., and Bacchetti, S. (1995). "Telomerase activity in normal leukocytes and in hematologic malignancies." Blood 85(9):2315-2320. PubMed
Counter, C. M., Meyerson, M., Eaton, E. N., Ellisen, L. W., Caddle, S. D., Haber, D. A., and Weinberg, R. A. (1998). "Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase." Oncogene 16(9):1217-1222. PubMed
Craik, F. I. M., and Salthouse, T. A. (1992). Handbook of Aging and Cognition. Erlbaum, Hillsdale.
Cristofalo, V. J., and Sharf, B. B. (1973). "Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid cells." Exp Cell Res 76(2):419-427. PubMed
Cristofalo, V. J., and Pignolo, R. J. (1993). "Replicative senescence of human fibroblast-like cells in culture." Physiol Rev 73(3):617-638. PubMed
Cristofalo, V. J., Volker, C., Francis, M. K., and Tresini, M. (1998a). "Age-dependent modifications of gene expression in human fibroblasts." Crit Rev Eukaryot Gene Expr 8(1):43-80. PubMed
Cristofalo, V. J., Allen, R. G., Pignolo, R. J., Martin, B. G., and Beck, J. C. (1998b). "Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation." Proc Natl Acad Sci U S A 95(18):10614-10619. PubMed
Cristofalo, V. (2001). ""I no longer believe that cell death is programmed. ..", an interview with Vincent Cristofalo." Biogerontology 2(4):283-290. PubMed
Cutler, R. G. (1975). "Evolution of human longevity and the genetic complexity governing aging rate." Proc Natl Acad Sci U S A 72(11):4664-4668. PubMed
Cutler, R. G. (1979). "Evolution of human longevity: a critical overview." Mech Ageing Dev 9(3-4):337-354. PubMed
Cutler, R. G. (1985). "Antioxidants and longevity of mammalian species." Basic Life Sci 35:15-73. PubMed
Das, M., Gabriely, I., and Barzilai, N. (2004). "Caloric restriction, body fat and ageing in experimental models." Obes Rev 5(1):13-19. PubMed
Davenport, R. J. (2003). "Power to the people." Sci Aging Knowledge Environ 2003(50):NS8. PubMed
de Boer, J., Andressoo, J. O., de Wit, J., Huijmans, J., Beems, R. B., van Steeg, H., Weeda, G., van der Horst, G. T., van Leeuwen, W., Themmen, A. P., et al. (2002). "Premature aging in mice deficient in DNA repair and transcription." Science 296(5571):1276-1279. PubMed
de Bruin, J. P., Bovenhuis, H., van Noord, P. A., Pearson, P. L., van Arendonk, J. A., te Velde, E. R., Kuurman, W. W., and Dorland, M. (2001). "The role of genetic factors in age at natural menopause." Hum Reprod 16(9):2014-2018. PubMed
de Grey, A. D. (1997). "A proposed refinement of the mitochondrial free radical theory of aging." Bioessays 19(2):161-166. PubMed
de Grey, A. D., Ames, B. N., Andersen, J. K., Bartke, A., Campisi, J., Heward, C. B., McCarter, R. J., and Stock, G. (2002). "Time to talk SENS: critiquing the immutability of human aging." Ann N Y Acad Sci 959:452-462; discussion 463-455. PubMed
de Grey, A. D. (2003). "An engineer's approach to the development of real anti-aging medicine." Sci Aging Knowledge Environ 2003(1):VP1. PubMed
de Grey, A. D. (2005). "The unfortunate influence of the weather on the rate of ageing: why human caloric restriction or its emulation may only extend life expectancy by 2-3 years." Gerontology 51(2):73-82. PubMed
de Haan, G., and Van Zant, G. (1999). "Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span." Faseb J 13(6):707-713. PubMed
de Magalhaes, J. P., and Toussaint, O. (2002). "The evolution of mammalian aging." Exp Gerontol 37(6):769-775. PubMed
de Magalhaes, J. P. (2003). "Is mammalian aging genetically controlled?" Biogerontology 4(2):119-120. PubMed
de Magalhaes, J. P. (2004). "From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing." Exp Cell Res 300(1):1-10. PubMed
de Magalhaes, J. P., and Toussaint, O. (2004a). "Telomeres and telomerase: a modern fountain of youth?" Rejuvenation Res 7(2):126-133. PubMed
de Magalhaes, J. P., and Toussaint, O. (2004b). "How bioinformatics can help reverse engineer human aging." Ageing Res Rev 3(2):125-141. PubMed
de Magalhaes, J. P. (2005a). "Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations." Ageing Res Rev 4(1):1-22. PubMed
de Magalhaes, J. P. (2005b). "Human disease-associated mitochondrial mutations fixed in nonhuman primates." J Mol Evol 61(4):491-497. PubMed
de Magalhaes, J. P., and Church, G. M. (2005). "Genomes optimize reproduction: aging as a consequence of the developmental program." Physiology (Bethesda) 20:252-259. PubMed
de Magalhaes, J. P., and Sandberg, A. (2005). "Cognitive aging as an extension of brain development: A model linking learning, brain plasticity, and neurodegeneration." Mech Ageing Dev 126(10):1026-1033. PubMed
de Magalhaes, J. P., Cabral, J. A., and Magalhaes, D. (2005a). "The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging." Genetics 169(1):265-274. PubMed
de Magalhaes, J. P., Costa, J., and Toussaint, O. (2005b). "HAGR: the Human Ageing Genomic Resources." Nucleic Acids Res 33 Database Issue:D537-543. PubMed
de Magalhaes, J. P., and Church, G. M. (2006). "Cells discover fire: employing reactive oxygen species in development and consequences for aging." Exp Gerontol 41(1):1-10. PubMed
de Magalhaes, J. P., Costa, J., and Church, G. M. (2007). "An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts." J Gerontol A Biol Sci Med Sci 62(2):149-160. PubMed
Decary, S., Mouly, V., Hamida, C. B., Sautet, A., Barbet, J. P., and Butler-Browne, G. S. (1997). "Replicative potential and telomere length in human skeletal muscle: implications for satellite cell-mediated gene therapy." Hum Gene Ther 8(12):1429-1438. PubMed
DiGiovanna, A. G. (2000). Human Aging: Biological Perspectives. McGraw-Hill, New York.
Dillin, A., Crawford, D. K., and Kenyon, C. (2002). "Timing requirements for insulin/IGF-1 signaling in C. elegans." Science 298(5594):830-834. PubMed
DiMauro, S., Tanji, K., Bonilla, E., Pallotti, F., and Schon, E. A. (2002). "Mitochondrial abnormalities in muscle and other aging cells: classification, causes, and effects." Muscle Nerve 26(5):597-607. PubMed
DiMauro, S., and Schon, E. A. (2003). "Mitochondrial respiratory-chain diseases." N Engl J Med 348(26):2656-2668. PubMed
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., Pereira-Smith, O., et al. (1995). "A biomarker that identifies senescent human cells in culture and in aging skin in vivo." Proc Natl Acad Sci U S A 92(20):9363-9367. PubMed
Dirks, A. J., and Leeuwenburgh, C. (2006). "Caloric restriction in humans: potential pitfalls and health concerns." Mech Ageing Dev 127(1):1-7. PubMed
Dolle, M. E., Giese, H., Hopkins, C. L., Martus, H. J., Hausdorff, J. M., and Vijg, J. (1997). "Rapid accumulation of genome rearrangements in liver but not in brain of old mice." Nat Genet 17(4):431-434. PubMed
Dolle, M. E., and Vijg, J. (2002). "Genome dynamics in aging mice." Genome Res 12(11):1732-1738. PubMed
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Jr., Butel, J. S., and Bradley, A. (1992). "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours." Nature 356(6366):215-221. PubMed
Donehower, L. A. (2002). "Does p53 affect organismal aging?" J Cell Physiol 192(1):23-33. PubMed
Drexler, E. K. (1986). Engines of Creation. Anchor Press, Garden City.
Ducray, C., Pommier, J. P., Martins, L., Boussin, F. D., and Sabatier, L. (1999). "Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process." Oncogene 18(29):4211-4223. PubMed
Duffy, P. H., Feuers, R., Nakamura, K. D., Leakey, J., and Hart, R. W. (1990). "Effect of chronic caloric restriction on the synchronization of various physiological measures in old female Fischer 344 rats." Chronobiol Int 7(2):113-124. PubMed
Dulic, V., Beney, G. E., Frebourg, G., Drullinger, L. F., and Stein, G. H. (2000). "Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts." Mol Cell Biol 20(18):6741-6754. PubMed
Dumont, P., Burton, M., Chen, Q. M., Gonos, E. S., Frippiat, C., Mazarati, J. B., Eliaers, F., Remacle, J., and Toussaint, O. (2000a). "Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast." Free Radical Biol Med 28(3):361-373. PubMed
Dumont, P., Balbeur, L., Remacle, J., and Toussaint, O. (2000b). "Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition." J Anat 197 Pt 4:529-537. PubMed
Dunham, M. A., Neumann, A. A., Fasching, C. L., and Reddel, R. R. (2000). "Telomere maintenance by recombination in human cells." Nat Genet 26(4):447-450. PubMed
Dyson, N., Howley, P. M., Munger, K., and Harlow, E. (1989). "The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product." Science 243(4893):934-937. PubMed
Edamatsu, R., Mori, A., and Packer, L. (1995). "The spin-trap N-tert-alpha-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse." Biochem Biophys Res Commun 211(3):847-849. PubMed
Effros, R. B. (1996). "Insights on immunological aging derived from the T lymphocyte cellular senescence model." Exp Gerontol 31(1-2):21-27. PubMed
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., and Cawthon, R. M. (2004). "Accelerated telomere shortening in response to life stress." Proc Natl Acad Sci U S A 101(49):17312-17315. PubMed
Eriksson, P. S., Perfilieva, E., Bjork-Eriksson, T., Alborn, A. M., Nordborg, C., Peterson, D. A., and Gage, F. H. (1998). "Neurogenesis in the adult human hippocampus." Nat Med 4(11):1313-1317. PubMed
Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J., Scott, L., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al. (2003). "Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome." Nature 423(6937):293-298. PubMed
Esposito, D., Fassina, G., Szabo, P., De Angelis, P., Rodgers, L., Weksler, M., and Siniscalco, M. (1989). "Chromosomes of older humans are more prone to aminopterine-induced breakage." Proc Natl Acad Sci U S A 86(4):1302-1306. PubMed
Fargnoli, J., Kunisada, T., Fornace, A. J., Jr., Schneider, E. L., and Holbrook, N. J. (1990). "Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats." Proc Natl Acad Sci U S A 87(2):846-850. PubMed
Fearon, E. R. (1997). "Human cancer syndromes: clues to the origin and nature of cancer." Science 278(5340):1043-1050. PubMed
Feng, J., Funk, W. D., Wang, S. S., Weinrich, S. L., Avilion, A. A., Chiu, C. P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995). "The RNA component of human telomerase." Science 269(5228):1236-1241. PubMed
Finch, C. E., and Pike, M. C. (1996). "Maximum life span predictions from the Gompertz mortality model." J Gerontol A Biol Sci Med Sci 51(3):B183-194. PubMed
Fleming, J. E., Reveillaud, I., and Niedzwiecki, A. (1992). "Role of oxidative stress in Drosophila aging." Mutat Res 275(3-6):267-279. PubMed
Flurkey, K., Papaconstantinou, J., Miller, R. A., and Harrison, D. E. (2001). "Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production." Proc Natl Acad Sci U S A 98(12):6736-6741. PubMed
Font, E., Desfilis, E., Perez-Canellas, M. M., and Garcia-Verdugo, J. M. (2001). "Neurogenesis and neuronal regeneration in the adult reptilian brain." Brain Behav Evol 58(5):276-295. PubMed
Fontana, L., Meyer, T. E., Klein, S., and Holloszy, J. O. (2004). "Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans." Proc Natl Acad Sci U S A 101(17):6659-6663. PubMed
Fontana, L., and Klein, S. (2007). "Aging, adiposity, and calorie restriction." Jama 297(9):986-994. PubMed
Forster, M. J., Morris, P., and Sohal, R. S. (2003). "Genotype and age influence the effect of caloric intake on mortality in mice." Faseb J 17(6):690-692. PubMed
Fossel, M. (1996). Reversing Human Aging. William Morrow and Company, New York.
Franceschi, C., Mondello, C., Bonafe, M., Valensin, S., Sansoni, P., and Sorbi, S. (1999). "Long telomeres and well preserved proliferative vigor in cells from centenarians: a contribution to longevity?" Aging (Milano) 11(2):69-72. PubMed
Freitas, R. (1999). Nanomedicine, Volume I: Basic Capabilities. Landes Bioscience, Georgetown.
Freitas, R. (2003). Nanomedicine, Volume IIA: Biocompatibility. Landes Bioscience, Georgetown.
Friguet, B., Bulteau, A. L., Chondrogianni, N., Conconi, M., and Petropoulos, I. (2000). "Protein degradation by the proteasome and its implications in aging." Ann N Y Acad Sci 908:143-154. PubMed
Froy, O., and Miskin, R. (2007). "The interrelations among feeding, circadian rhythms and ageing." Prog Neurobiol 82(3):142-150. PubMed
Fry, M. (2002). "The Werner syndrome helicase-nuclease--one protein, many mysteries." Sci Aging Knowledge Environ 2002(13):re2. PubMed
Fujioka, K., Greenway, F., Sheard, J., and Ying, Y. (2006). "The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome." J Med Food 9(1):49-54. PubMed
Fukuchi, K., Martin, G. M., and Monnat, R. J., Jr. (1989). "Mutator phenotype of Werner syndrome is characterized by extensive deletions." Proc Natl Acad Sci U S A 86(15):5893-5897. PubMed
Funk, W. D., Wang, C. K., Shelton, D. N., Harley, C. B., Pagon, G. D., and Hoeffler, W. K. (2000). "Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model." Exp Cell Res 258(2):270-278. PubMed
Gallo, R. C., and Montagnier, L. (2003). "The discovery of HIV as the cause of AIDS." N Engl J Med 349(24):2283-2285. PubMed
Gardner, E. M. (2005). "Caloric restriction decreases survival of aged mice in response to primary influenza infection." J Gerontol A Biol Sci Med Sci 60(6):688-694. PubMed
Gavrilov, L. A., and Gavrilova, N. S. (2002). "Evolutionary theories of aging and longevity." ScientificWorldJournal 2:339-356. PubMed
Gebhart, E., Bauer, R., Raub, U., Schinzel, M., Ruprecht, K. W., and Jonas, J. B. (1988). "Spontaneous and induced chromosomal instability in Werner syndrome." Hum Genet 80(2):135-139. PubMed
Geiger, H., and Van Zant, G. (2002). "The aging of lympho-hematopoietic stem cells." Nat Immunol 3(4):329-333. PubMed
Gensler, H. L., and Bernstein, H. (1981). "DNA damage as the primary cause of aging." Q Rev Biol 56(3):279-303. PubMed
Gerland, L. M., Peyrol, S., Lallemand, C., Branche, R., Magaud, J. P., and Ffrench, M. (2003). "Association of increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging." Exp Gerontol 38(8):887-895. PubMed
Gerschman, R., Gilbert, D. L., Nye, S. W., Dwyer, P., and Fenn, W. O. (1954). "Oxygen poisoning and x-irradiation: a mechanism in common." Science 119(3097):623-626. PubMed
Gershon, H., and Gershon, D. (1970). "Detection of inactive enzyme molecules in ageing organisms." Nature 227(5264):1214-1217. PubMed
Gershon, H., and Gershon, D. (2000a). "Paradigms in aging research: a critical review and assessment." Mech Ageing Dev 117(1-3):21-28. PubMed
Gershon, H., and Gershon, D. (2000b). "The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review." Mech Ageing Dev 120(1-3):1-22. PubMed
Giacomoni, P. U., Declercq, L., Hellemans, L., and Maes, D. (2000). "Aging of human skin: review of a mechanistic model and first experimental data." IUBMB Life 49(4):259-263. PubMed
Gire, V., and Wynford-Thomas, D. (1998). "Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies." Mol Cell Biol 18(3):1611-1621. PubMed
Going, J. J., Stuart, R. C., Downie, M., Fletcher-Monaghan, A. J., and Keith, W. N. (2002). "'Senescence-associated' beta-galactosidase activity in the upper gastrointestinal tract." J Pathol 196(4):394-400. PubMed
Goldsmith, T. C. (2004). "Aging as an evolved characteristic - Weismann's theory reconsidered." Med Hypotheses 62(2):304-308. PubMed
Goldstein, S. (1974). "Aging in vitro. Growth of cultured cells from the Galapagos tortoise." Exp Cell Res 83(2):297-302. PubMed
Goldstein, S. (1990). "Replicative senescence: the human fibroblast comes of age." Science 249(4973):1129-1133. PubMed
Gonos, E. S., Derventzi, A., Kveiborg, M., Agiostratidou, G., Kassem, M., Clark, B. F., Jat, P. S., and Rattan, S. I. (1998). "Cloning and identification of genes that associate with mammalian replicative senescence." Exp Cell Res 240(1):66-74. PubMed
Gonzalez-Suarez, E., Samper, E., Flores, J. M., and Blasco, M. A. (2000). "Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis." Nat Genet 26(1):114-117. PubMed
Gonzalez-Suarez, E., Samper, E., Ramirez, A., Flores, J. M., Martin-Caballero, J., Jorcano, J. L., and Blasco, M. A. (2001). "Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes." Embo J 20(11):2619-2630. PubMed
Goodrich, D. W., and Lee, W. H. (1993). "Molecular characterization of the retinoblastoma susceptibility gene." Biochim Biophys Acta 1155(1):43-61. PubMed
Gosden, R. (1996). Cheating Time. W. H. Freeman & Company, New York.
Goto, M. (1997). "Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing." Mech Ageing Dev 98(3):239-254. PubMed
Gould, E., Reeves, A. J., Graziano, M. S., and Gross, C. G. (1999). "Neurogenesis in the neocortex of adult primates." Science 286(5439):548-552. PubMed
Gray, M. D., Shen, J. C., Kamath-Loeb, A. S., Blank, A., Sopher, B. L., Martin, G. M., Oshima, J., and Loeb, L. A. (1997). "The Werner syndrome protein is a DNA helicase." Nat Genet 17(1):100-103. PubMed
Greenberg, J. A., and Boozer, C. N. (2000). "Metabolic mass, metabolic rate, caloric restriction, and aging in male Fischer 344 rats." Mech Ageing Dev 113(1):37-48. PubMed
Greider, C. W., and Blackburn, E. H. (1985). "Identification of a specific telomere terminal transferase activity in Tetrahymena extracts." Cell 43(2 Pt 1):405-413. PubMed
Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., and de Lange, T. (1999). "Mammalian telomeres end in a large duplex loop." Cell 97(4):503-514. PubMed
Grossman, C. J. (1984). "Regulation of the immune system by sex steroids." Endocr Rev 5(3):435-455. PubMed
Grube, K., and Burkle, A. (1992). "Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span." Proc Natl Acad Sci U S A 89(24):11759-11763. PubMed
Gurdon, J. B., Laskey, R. A., and Reeves, O. R. (1975). "The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs." J Embryol Exp Morphol 34(1):93-112. PubMed
Hahn, W. C. (2003). "Role of telomeres and telomerase in the pathogenesis of human cancer." J Clin Oncol 21(10):2034-2043. PubMed
Hamad, N. M., Elconin, J. H., Karnoub, A. E., Bai, W., Rich, J. N., Abraham, R. T., Der, C. J., and Counter, C. M. (2002). "Distinct requirements for Ras oncogenesis in human versus mouse cells." Genes Dev 16(16):2045-2057. PubMed
Hamilton, W. D. (1966). "The moulding of senescence by natural selection." J Theor Biol 12(1):12-45. PubMed
Hamilton, J. B., and Mestler, G. E. (1969). "Mortality and survival: comparison of eunuchs with intact men and women in a mentally retarded population." J Gerontol 24(4):395-411. PubMed
Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., and Richardson, A. (2001). "Does oxidative damage to DNA increase with age?" Proc Natl Acad Sci U S A 98(18):10469-10474. PubMed
Hammerman, M. R. (1987). "Insulin-like growth factors and aging." Endocrinol Metab Clin North Am 16(4):995-1011. PubMed
Hande, M. P., Samper, E., Lansdorp, P., and Blasco, M. A. (1999). "Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice." J Cell Biol 144(4):589-601. PubMed
Hara, E., Tsurui, H., Shinozaki, A., Nakada, S., and Oda, K. (1991). "Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1." Biochem Biophys Res Commun 179(1):528-534. PubMed
Hara, E., Smith, R., Parry, D., Tahara, H., Stone, S., and Peters, G. (1996). "Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence." Mol Cell Biol 16(3):859-867. PubMed
Harada, T., Tokuriki, M., and Tanioka, Y. (1999). "Age-related changes in the brainstem auditory evoked potentials of the marmoset." Hear Res 128(1-2):119-124. PubMed
Hari, R., Burde, V., and Arking, R. (1998). "Immunological confirmation of elevated levels of CuZn superoxide dismutase protein in an artificially selected long-lived strain of Drosophila melanogaster." Exp Gerontol 33(3):227-237. PubMed
Harle-Bachor, C., and Boukamp, P. (1996). "Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes." Proc Natl Acad Sci U S A 93(13):6476-6481. PubMed
Harley, C. B., Pollard, J. W., Chamberlain, J. W., Stanners, C. P., and Goldstein, S. (1980). "Protein synthetic errors do not increase during aging of cultured human fibroblasts." Proc Natl Acad Sci U S A 77(4):1885-1889. PubMed
Harley, C. B., Futcher, A. B., and Greider, C. W. (1990). "Telomeres shorten during ageing of human fibroblasts." Nature 345(6274):458-460. PubMed
Harman, D. (1956). "Aging: a theory based on free radical and radiation chemistry." J Gerontol 11(3):298-300. PubMed
Harman, D. (1968). "Free radical theory of aging: effect of free radical reaction inhibitors on the mortality rate of male LAF mice." J Gerontol 23(4):476-482. PubMed
Harman, D. (1972). "The biologic clock: the mitochondria?" J Am Geriatr Soc 20(4):145-147. PubMed
Harman, D. (1981). "The aging process." Proc Natl Acad Sci U S A 78(11):7124-7128. PubMed
Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. (1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases." Cell 75(4):805-816. PubMed
Harper, J. W., Elledge, S. J., Keyomarsi, K., Dynlacht, B., Tsai, L. H., Zhang, P., Dobrowolski, S., Bai, C., Connell-Crowley, L., Swindell, E., et al. (1995). "Inhibition of cyclin-dependent kinases by p21." Mol Biol Cell 6(4):387-400. PubMed
Harper, J. M., Leathers, C. W., and Austad, S. N. (2006). "Does caloric restriction extend life in wild mice?" Aging Cell 5(6):441-449. PubMed
Hart, R. W., and Setlow, R. B. (1974). "Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species." Proc Natl Acad Sci U S A 71(6):2169-2173. PubMed
Harvey, P. H., and Zammuto, R. M. (1985). "Patterns of mortality and age at first reproduction in natural populations of mammals." Nature 315(6017):319-320. PubMed
Haseltine, W. A. (2004). "An interview with William A. Haseltine." Rejuvenation Res 7(3):229-231. PubMed
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., and Allshire, R. C. (1990). "Telomere reduction in human colorectal carcinoma and with ageing." Nature 346(6287):866-868. PubMed
Hasty, J., McMillen, D., and Collins, J. J. (2002). "Engineered gene circuits." Nature 420(6912):224-230. PubMed
Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., and Vijg, J. (2003). "Aging and genome maintenance: lessons from the mouse?" Science 299(5611):1355-1359. PubMed
Hasty, P., and Vijg, J. (2004). "Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity." Aging Cell 3(2):55-65. PubMed
Haussmann, M. F., Winkler, D. W., O'Reilly, K. M., Huntington, C. E., Nisbet, I. C., and Vleck, C. M. (2003). "Telomeres shorten more slowly in long-lived birds and mammals than in short-lived ones." Proc R Soc Lond B Biol Sci 270(1522):1387-1392. PubMed
Hayflick, L., and Moorhead, P. S. (1961). "The serial cultivation of human diploid cell strains." Exp Cell Res 25:585-621. PubMed
Hayflick, L. (1985). "The cell biology of aging." Clin Geriatr Med 1(1):15-27. PubMed
Hayflick, L. (1994). How and Why We Age. Ballantine Books, New York.
Hayflick, L. (2000). "The future of ageing." Nature 408(6809):267-269. PubMed
Hayflick, L. (2004). ""Anti-aging" is an oxymoron." J Gerontol A Biol Sci Med Sci 59(6):B573-578. PubMed
Hedges, S. B. (2002). "The origin and evolution of model organisms." Nat Rev Genet 3(11):838-849. PubMed
Heidrick, M. L., Hendricks, L. C., and Cook, D. E. (1984). "Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice." Mech Ageing Dev 27(3):341-358. PubMed
Heilbronn, L. K., de Jonge, L., Frisard, M. I., DeLany, J. P., Larson-Meyer, D. E., Rood, J., Nguyen, T., Martin, C. K., Volaufova, J., Most, M. M., et al. (2006). "Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial." Jama 295(13):1539-1548. PubMed
Hemann, M. T., and Greider, C. W. (2000). "Wild-derived inbred mouse strains have short telomeres." Nucleic Acids Res 28(22):4474-4478. PubMed
Hemann, M. T., Strong, M. A., Hao, L. Y., and Greider, C. W. (2001). "The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability." Cell 107(1):67-77. PubMed
Henning, K. A., Li, L., Iyer, N., McDaniel, L. D., Reagan, M. S., Legerski, R., Schultz, R. A., Stefanini, M., Lehmann, A. R., Mayne, L. V., et al. (1995). "The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH." Cell 82(4):555-564. PubMed
Herwig, S., and Strauss, M. (1997). "The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis." Eur J Biochem 246(3):581-601. PubMed
Hill, K., Boesch, C., Goodall, J., Pusey, A., Williams, J., and Wrangham, R. (2001). "Mortality rates among wild chimpanzees." J Hum Evol 40(5):437-450. PubMed
Ho, K. Y., Evans, W. S., Blizzard, R. M., Veldhuis, J. D., Merriam, G. R., Samojlik, E., Furlanetto, R., Rogol, A. D., Kaiser, D. L., and Thorner, M. O. (1987). "Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations." J Clin Endocrinol Metab 64(1):51-58. PubMed
Ho, Y. S., Magnenat, J. L., Bronson, R. T., Cao, J., Gargano, M., Sugawara, M., and Funk, C. D. (1997). "Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia." J Biol Chem 272(26):16644-16651. PubMed
Holliday, R. (1984). "The biological significance of meiosis." Symp Soc Exp Biol 38:381-394. PubMed
Holliday, R. (1995). Understanding Ageing. Cambridge University Press, Cambridge.
Holliday, R. (2004). "The multiple and irreversible causes of aging." J Gerontol A Biol Sci Med Sci 59(6):B568-572. PubMed
Holloszy, J. O., and Smith, E. K. (1986). "Longevity of cold-exposed rats: a reevaluation of the "rate-of-living theory"." J Appl Physiol 61(5):1656-1660. PubMed
Holloszy, J. O., and Schechtman, K. B. (1991). "Interaction between exercise and food restriction: effects on longevity of male rats." J Appl Physiol 70(4):1529-1535. PubMed
Holloszy, J. O. (1997). "Mortality rate and longevity of food-restricted exercising male rats: a reevaluation." J Appl Physiol 82(2):399-403. PubMed
Holloszy, J. O. (1998). "Longevity of exercising male rats: effect of an antioxidant supplemented diet." Mech Ageing Dev 100(3):211-219. PubMed
Holloszy, J. O. (2000). "The biology of aging." Mayo Clin Proc 75 Suppl:S3-8; discussion S8-9. PubMed
Holmes, D. J., and Austad, S. N. (1995). "Birds as animal models for the comparative biology of aging: a prospectus." J Gerontol A Biol Sci Med Sci 50(2):B59-66. PubMed
Holmes, D. J., Fluckiger, R., and Austad, S. N. (2001). "Comparative biology of aging in birds: an update." Exp Gerontol 36(4-6):869-883. PubMed
Holmes, D. J., and Ottinger, M. A. (2003). "Birds as long-lived animal models for the study of aging." Exp Gerontol 38(11-12):1365-1375. PubMed
Hopkin, K. (2003). "Dietary drawbacks." Sci Aging Knowledge Environ 2003(8):NS4. PubMed
Horikoshi, T., Balin, A. K., and Carter, D. M. (1986). "Effect of oxygen on the growth of human epidermal keratinocytes." J Invest Dermatol 86(4):424-427. PubMed
Horikoshi, T., Balin, A. K., and Carter, D. M. (1991). "Effects of oxygen tension on the growth and pigmentation of normal human melanocytes." J Invest Dermatol 96(6):841-844. PubMed
Horwitz, E. M., Prockop, D. J., Fitzpatrick, L. A., Koo, W. W., Gordon, P. L., Neel, M., Sussman, M., Orchard, P., Marx, J. C., Pyeritz, R. E., et al. (1999). "Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta." Nat Med 5(3):309-313. PubMed
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L., et al. (2003). "Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan." Nature 425(6954):191-196. PubMed
Hsin, H., and Kenyon, C. (1999). "Signals from the reproductive system regulate the lifespan of C. elegans." Nature 399(6734):362-366. PubMed
Huang, S., Li, B., Gray, M. D., Oshima, J., Mian, I. S., and Campisi, J. (1998). "The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease." Nat Genet 20(2):114-116. PubMed
Huang, T. T., Carlson, E. J., Gillespie, A. M., Shi, Y., and Epstein, C. J. (2000). "Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice." J Gerontol A Biol Sci Med Sci 55(1):B5-9. PubMed
Hughes, K. A., Alipaz, J. A., Drnevich, J. M., and Reynolds, R. M. (2002). "A test of evolutionary theories of aging." Proc Natl Acad Sci U S A 99(22):14286-14291. PubMed
Hussussian, C. J., Struewing, J. P., Goldstein, A. M., Higgins, P. A., Ally, D. S., Sheahan, M. D., Clark, W. H., Jr., Tucker, M. A., and Dracopoli, N. C. (1994). "Germline p16 mutations in familial melanoma." Nat Genet 8(1):15-21. PubMed
Hwang, S. J., Lozano, G., Amos, C. I., and Strong, L. C. (2003). "Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk." Am J Hum Genet 72(4):975-983. PubMed
Hwang, W. S., Ryu, Y. J., Park, J. H., Park, E. S., Lee, E. G., Koo, J. M., Jeon, H. Y., Lee, B. C., Kang, S. K., Kim, S. J., et al. (2004). "Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst." Science 303(5664):1669-1674. PubMed
Hwang, W. S., Roh, S. I., Lee, B. C., Kang, S. K., Kwon, D. K., Kim, S., Kim, S. J., Park, S. W., Kwon, H. S., Lee, C. K., et al. (2005). "Patient-specific embryonic stem cells derived from human SCNT blastocysts." Science 308(5729):1777-1783. PubMed
Ingram, D. K., Roth, G. S., Lane, M. A., Ottinger, M. A., Zou, S., de Cabo, R., and Mattison, J. A. (2006). "The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies." Biogerontology 7(3):143-148. PubMed
Inoue, S., Koya-Miyata, S., Ushio, S., Iwaki, K., Ikeda, M., and Kurimoto, M. (2003). "Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage." Exp Gerontol 38(9):965-969. PubMed
Iwama, H., Ohyashiki, K., Ohyashiki, J. H., Hayashi, S., Yahata, N., Ando, K., Toyama, K., Hoshika, A., Takasaki, M., Mori, M., et al. (1998). "Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals." Hum Genet 102(4):397-402. PubMed
Ja, W. W., West, A. P., Jr., Delker, S. L., Bjorkman, P. J., Benzer, S., and Roberts, R. W. (2007). "Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor." Nat Chem Biol 3(7):415-419. PubMed
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W., Fong, H. H., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997). "Cancer chemopreventive activity of resveratrol, a natural product derived from grapes." Science 275(5297):218-220. PubMed
Janzen, D. H. (1976). "Why bamboos wait so long to flower." Ann Rev Ecol Sys 7:347-391.
Jazwinski, S. M. (1990). "Aging and senescence of the budding yeast Saccharomyces cerevisiae." Mol Microbiol 4(3):337-343. PubMed
Jazwinski, S. M. (2001). "New clues to old yeast." Mech Ageing Dev 122(9):865-882. PubMed
Jazwinski, S. M. (2005). "Yeast longevity and aging--the mitochondrial connection." Mech Ageing Dev 126(2):243-248. PubMed
Jena, B. S., Nayak, S. B., and Patnaik, B. K. (2002). "Age-related effect of aluminium on the catalase activities of the brains of two species of poikilothermic vertebrates." Gerontology 48(1):34-38. PubMed
Jiang, X. R., Jimenez, G., Chang, E., Frolkis, M., Kusler, B., Sage, M., Beeche, M., Bodnar, A. G., Wahl, G. M., Tlsty, T. D., et al. (1999). "Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype." Nat Genet 21(1):111-114. PubMed
Johnson, T. E., Mitchell, D. H., Kline, S., Kemal, R., and Foy, J. (1984). "Arresting development arrests aging in the nematode Caenorhabditis elegans." Mech Ageing Dev 28(1):23-40. PubMed
Johnson, T. E. (1990). "Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging." Science 249(4971):908-912. PubMed
Johnson, F. B., Sinclair, D. A., and Guarente, L. (1999). "Molecular biology of aging." Cell 96(2):291-302. PubMed
Johnson, T. E. (2002). "A personal retrospective on the genetics of aging." Biogerontology 3(1-2):7-12. PubMed
Jolly, C. A., Muthukumar, A., Avula, C. P., Troyer, D., and Fernandes, G. (2001). "Life span is prolonged in food-restricted autoimmune-prone (NZB x NZW)F(1) mice fed a diet enriched with (n-3) fatty acids." J Nutr 131(10):2753-2760. PubMed
Jurgens, K. D., and Prothero, J. (1987). "Scaling of maximal lifespan in bats." Comp Biochem Physiol A 88(2):361-367. PubMed
Kakuo, S., Asaoka, K., and Ide, T. (1999). "Human is a unique species among primates in terms of telomere length." Biochem Biophys Res Commun 263(2):308-314. PubMed
Kammori, M., Nakamura, K. I., Kawahara, M., Mimura, Y., Kaminishi, M., and Takubo, K. (2002). "Telomere shortening with aging in human thyroid and parathyroid tissue." Exp Gerontol 37(4):513-521. PubMed
Kanungo, M. S. (1994). Genes and Aging. Cambridge University Press, Cambridge, UK.
Kapahi, P., Boulton, M. E., and Kirkwood, T. B. (1999). "Positive correlation between mammalian life span and cellular resistance to stress." Free Radic Biol Med 26(5-6):495-500. PubMed
Kaplan, H. S., and Robson, A. J. (2002). "The emergence of humans: the coevolution of intelligence and longevity with intergenerational transfers." Proc Natl Acad Sci U S A 99(15):10221-10226. PubMed
Kara, T. C. (1994). "Ageing in amphibians." Gerontology 40(2-4):161-173. PubMed
Karakashian, S. J., Lanners, H. N., and Rudzinska, M. A. (1984). "Cellular and clonal aging in the suctorian protozoan Tokophrya infusionum." Mech Ageing Dev 26(2-3):217-229. PubMed
Karasek, M. (2004). "Melatonin, human aging, and age-related diseases." Exp Gerontol 39(11-12):1723-1729. PubMed
Karatza, C., Stein, W. D., and Shall, S. (1984). "Kinetics of in vitro ageing of mouse embryo fibroblasts." J Cell Sci 65:163-175. PubMed
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., and de Lange, T. (1999). "p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2." Science 283(5406):1321-1325. PubMed
Karlseder, J., Smogorzewska, A., and de Lange, T. (2002). "Senescence induced by altered telomere state, not telomere loss." Science 295(5564):2446-2449. PubMed
Kealy, R. D., Lawler, D. F., Ballam, J. M., Mantz, S. L., Biery, D. N., Greeley, E. H., Lust, G., Segre, M., Smith, G. K., and Stowe, H. D. (2002). "Effects of diet restriction on life span and age-related changes in dogs." J Am Vet Med Assoc 220(9):1315-1320. PubMed
Keaney, M., and Gems, D. (2003). "No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8." Free Radic Biol Med 34(2):277-282. PubMed
Keaney, M., Matthijssens, F., Sharpe, M., Vanfleteren, J., and Gems, D. (2004). "Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans." Free Radic Biol Med 37(2):239-250. PubMed