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Welcome to senescence.info!

An educational and information resource on the science of aging

Amaranth flower

"The knowledge that every ambition is doomed to frustration at the hands of a skeleton have never prevented the majority of human beings from behaving as though death were no more than an unfounded rumor."

Aldous Huxley


Aging, or senescence, is the major cause of suffering, disease, and death in modern times. With the worldwide graying of the population, we are now aging for a longer period of time than ever before. Gerontology, and its sub-field biogerontology in particular, is the science that studies the aging process to prevent age-related disease and degeneration, preserve health, and prolong human life. senescence.info aims to highlight the importance of research on aging and give an overview of current knowledge on the biology and genetics of aging, including anti-aging therapies, models and theories of aging. The most ambitious, even if distant, goal of gerontological research is to make aging optional, to develop a cure for aging, and the social implications of a radical increase in human lifespan due to scientific breakthroughs are also discussed.

senescence.info is aimed at a vast audience and includes tutorials for the non-specialist. Though of course my personal points of view are more prevalent, I try to mention different perspectives, even if I do not agree with them. Although senescence.info is not peer-reviewed, it is used as a reference by scientists and students in the field and recognized as a major knowledge and information website on the aging process; as evidence of its academic standing, senescence.info has been highlighted in Science (307:187), Aging Cell (8:65) and Nucleic Acids Research (41:D1027).


Prologue

Why I study aging, what is on offer at senescence.info, my goals for this website, and how best to use its resources.

Visitor's Resources

An introduction to work done in the biology of aging, its importance, potential implications and career advice.

Gerontology Information

An overview of current research on the biology of human aging featuring key observations, concepts, and theories. Thanks to David Bahry, available is also a printer-friendly version .

Genomics of Aging

I am the principal investigator of the Integrative Genomics of Ageing Group at the University of Liverpool in the UK. Amongst other projects, we maintain the Human Ageing Genomic Resources, a series of tools and databases aimed at understanding the genetic basis of human aging.

  • GenAge is a curated database of genes related to aging in humans and in model organisms.

  • GenDR is the first database of dietary restriction-associated genes.

  • LongevityMap is the first database of human genetic variants associated with longevity.

  • AnAge is an aging-oriented animal database featuring over 4,000 species.

  • The Digital Ageing Atlas is the first centralized collection of aging changes and pathologies.

Human Ageing Genomic Resources

The Global Sphere

Cooperation and networking are keys to success.


Creation date: Circa 1997
Last modified: August 18, 2013

Thank you for visiting my website. Please feel free to contact me if you have any questions, ideas, comments or suggestions.

Copyright © 1997 - 2013 by João Pedro de Magalhães. All rights reserved.